Molecular-genetic imaging of cancer

Il Minn; Mitchell E Menezes; Siddik Sarkar; Keerthi Yarlagadda; Swadesh K Das; Luni Emdad; Devanand Sarkar; Paul B Fisher; Martin G Pomper

doi:10.1016/B978-0-12-411638-2.00004-5

Molecular-genetic imaging of cancer

Adv Cancer Res. 2014:124:131-69. doi: 10.1016/B978-0-12-411638-2.00004-5.

Authors

Il Minn¹, Mitchell E Menezes², Siddik Sarkar², Keerthi Yarlagadda¹, Swadesh K Das³, Luni Emdad⁴, Devanand Sarkar⁴, Paul B Fisher⁴, Martin G Pomper⁵

Affiliations

¹ Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.
² Department of Human and Molecular Genetics, Richmond, Virginia, USA.
³ Department of Human and Molecular Genetics, Richmond, Virginia, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.
⁴ Department of Human and Molecular Genetics, Richmond, Virginia, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.
⁵ Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: mpomper@jhmi.edu.

Abstract

Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.

Keywords: Bioluminescence; Metastasis; Molecular imaging; PET; Promoter.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Gene Expression*
Humans
Multimodal Imaging / methods*
Neoplasms / diagnosis*
Neoplasms / genetics*

Abstract

Publication types

MeSH terms

Grants and funding