Abstract
The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomyces / drug effects
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Ascomycota / chemistry*
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Bacteroides / drug effects
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Indole Alkaloids
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Marine Biology
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Microbial Sensitivity Tests
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Mitosporic Fungi
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Molecular Structure
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Peptostreptococcus / drug effects
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Perciformes / microbiology*
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Streptococcus / drug effects
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Tinidazole / pharmacology
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Veillonella / drug effects
Substances
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Alkaloids
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Anti-Bacterial Agents
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Indole Alkaloids
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curvulamine
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Tinidazole