Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species

Org Lett. 2014 Oct 17;16(20):5366-9. doi: 10.1021/ol502572g. Epub 2014 Oct 6.

Abstract

The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomyces / drug effects
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Ascomycota / chemistry*
  • Bacteroides / drug effects
  • Indole Alkaloids
  • Marine Biology
  • Microbial Sensitivity Tests
  • Mitosporic Fungi
  • Molecular Structure
  • Peptostreptococcus / drug effects
  • Perciformes / microbiology*
  • Streptococcus / drug effects
  • Tinidazole / pharmacology
  • Veillonella / drug effects

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Indole Alkaloids
  • curvulamine
  • Tinidazole