A ratiometric fluorescent probe for sensing HOCl based on a coumarin-rhodamine dyad

Chem Commun (Camb). 2014 Nov 25;50(91):14241-4. doi: 10.1039/c4cc05976j.

Abstract

We developed a ratiometric fluorescent probe for sensing HOCl based on coumarin and rhodamine acid that is directly used as a detection moiety. The probe shows high selectivity and sensitivity toward HOCl under best working conditions of myeloperoxidase by which HOCl can be generated from hydrogen peroxide and chloride.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Coumarins / chemistry*
  • Fluorescent Dyes / chemistry*
  • Hypochlorous Acid / analysis*
  • Mice
  • Molecular Structure
  • Rhodamines / chemistry*
  • Spectrometry, Fluorescence

Substances

  • Coumarins
  • Fluorescent Dyes
  • Rhodamines
  • Hypochlorous Acid
  • coumarin