Persistent spiking fever in a child with acute myeloid leukemia and disseminated infection with enterovirus

J L Murk; A C de Vries; C H GeurtsvanKessel; G Aron; A D Osterhaus; K C Wolthers; P L Fraaij

doi:10.1016/j.jcv.2014.09.006

Persistent spiking fever in a child with acute myeloid leukemia and disseminated infection with enterovirus

J Clin Virol. 2014 Nov;61(3):453-5. doi: 10.1016/j.jcv.2014.09.006. Epub 2014 Sep 26.

Authors

J L Murk¹, A C de Vries², C H GeurtsvanKessel³, G Aron³, A D Osterhaus³, K C Wolthers⁴, P L Fraaij⁵

Affiliations

¹ Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: j.murk@umcutrecht.nl.
² Department of Pediatric Oncology/Hematology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
³ Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
⁴ Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
⁵ Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Subdivision of Infectious Diseases and Immunology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.

PMID: 25281281
DOI: 10.1016/j.jcv.2014.09.006

Abstract

We here report a 7 year old acute myeloid leukemia patient with persistent spiking fever likely caused by chronic echovirus 20 infection. After immunoglobulin substitution fevers subsided and the virus was cleared. Enterovirus infection should be considered in immunocompromised patients with unexplained persistent fever.

Keywords: Acute myeloid leukemia; Echovirus 20; Enterovirus; Immunoglobulin therapy; Spiking fever.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Child
Echovirus Infections / diagnosis*
Echovirus Infections / pathology*
Enterovirus B, Human / isolation & purification*
Fever / etiology*
Humans
Immunocompromised Host
Immunoglobulins, Intravenous / therapeutic use
Leukemia, Myeloid, Acute / complications*
Leukemia, Myeloid, Acute / diagnosis*
Leukemia, Myeloid, Acute / pathology
Male
Treatment Outcome

Substances

Immunoglobulins, Intravenous