Abstract
Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Oxidoreductases / physiology*
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Epithelial Cells / metabolism*
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Epithelial-Mesenchymal Transition / physiology*
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Exfoliation Syndrome / metabolism*
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Extracellular Matrix / metabolism
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Glaucoma, Open-Angle / metabolism*
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Humans
Substances
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Amino Acid Oxidoreductases
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LOXL1 protein, human