Podosome rosettes precede vascular sprouts in tumour angiogenesis

Carmen M Warren; M Luisa Iruela-Arispe

doi:10.1038/ncb3044

Podosome rosettes precede vascular sprouts in tumour angiogenesis

Nat Cell Biol. 2014 Oct;16(10):928-30. doi: 10.1038/ncb3044.

Authors

Carmen M Warren¹, M Luisa Iruela-Arispe²

Affiliations

¹ Department of Molecular, Cell and Developmental Biology; University of California, Los Angeles, California 90095, USA.
² 1] Department of Molecular, Cell and Developmental Biology; University of California, Los Angeles, California 90095, USA [2] Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.

PMID: 25271481
PMCID: PMC8128323
DOI: 10.1038/ncb3044

Abstract

Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.

Publication types

News

MeSH terms

Basement Membrane / metabolism
Cell Membrane Structures / metabolism
Cell Membrane Structures / physiology*
Endothelial Cells / metabolism
Endothelial Cells / physiology*
Extracellular Matrix / metabolism
Humans
Integrin alpha6beta1 / metabolism
Models, Biological
Neoplasms / blood supply
Neoplasms / metabolism
Neoplasms / physiopathology*
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / physiopathology*

Substances

Integrin alpha6beta1

Grants and funding

T32 HL069766/HL/NHLBI NIH HHS/United States