Abstract
The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / toxicity
-
Biological Products / chemistry
-
Cell Line
-
Cell Survival / drug effects
-
Chemistry Techniques, Synthetic
-
Drug Discovery*
-
Heterocyclic Compounds / chemical synthesis
-
Heterocyclic Compounds / chemistry*
-
Heterocyclic Compounds / toxicity
-
Humans
-
Molecular Structure
Substances
-
Antineoplastic Agents
-
Biological Products
-
Heterocyclic Compounds