Biochemistry and medicinal chemistry of the dengue virus protease

Chem Rev. 2014 Nov 26;114(22):11348-81. doi: 10.1021/cr500233q. Epub 2014 Sep 30.

Authors

Christoph Nitsche¹, Steven Holloway², Tanja Schirmeister², Christian D Klein¹

Affiliations

¹ Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University , Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.
² Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz , Staudingerweg 5, D-55128 Mainz, Germany.

PMID: 25268322
DOI: 10.1021/cr500233q

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antiviral Agents / pharmacology
Dengue Virus / enzymology*
Peptide Hydrolases / chemistry
Peptide Hydrolases / metabolism*
Protease Inhibitors / pharmacology
Protein Conformation
Substrate Specificity

Substances

Antiviral Agents
Protease Inhibitors
Peptide Hydrolases