Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

R Koshida; L Vrang; G Gilljam; J Harmenberg; B Oberg; B Wahren

doi:10.1128/AAC.33.5.778

Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

Antimicrob Agents Chemother. 1989 May;33(5):778-80. doi: 10.1128/AAC.33.5.778.

Authors

R Koshida¹, L Vrang, G Gilljam, J Harmenberg, B Oberg, B Wahren

Affiliation

¹ Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.

Abstract

We describe a synergistic effect of combinations of foscarnet and 3'-azido-3'-deoxythymidine against human immunodeficiency virus type 1 multiplication in cell culture, an additive effect of foscarnet and 3'-azido-3'-deoxythymidine triphosphate against human immunodeficiency virus type 1 reverse transcriptase, and a low toxicity in cell culture of combinations of the two drugs.

MeSH terms

Antiviral Agents / pharmacology*
Antiviral Agents / toxicity
Cells, Cultured
Fluorescent Antibody Technique
Foscarnet
HIV-1 / drug effects*
Humans
Organophosphorus Compounds / pharmacology*
Phosphonoacetic Acid / analogs & derivatives
Phosphonoacetic Acid / pharmacology*
Phosphonoacetic Acid / toxicity
Zidovudine / pharmacology*
Zidovudine / toxicity

Substances

Antiviral Agents
Organophosphorus Compounds
Foscarnet
Zidovudine
Phosphonoacetic Acid