Acylphloroglucinol derivatives from Hypericum andinum: antidepressant-like activity of andinin A

Gari V Ccana-Ccapatinta; Eveline D Stolz; Paola F da Costa; Stela M K Rates; Gilsane L von Poser

doi:10.1021/np500426m

Acylphloroglucinol derivatives from Hypericum andinum: antidepressant-like activity of andinin A

J Nat Prod. 2014 Oct 24;77(10):2321-5. doi: 10.1021/np500426m. Epub 2014 Sep 29.

Authors

Gari V Ccana-Ccapatinta¹, Eveline D Stolz, Paola F da Costa, Stela M K Rates, Gilsane L von Poser

Affiliation

¹ Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul , Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.

PMID: 25264905
DOI: 10.1021/np500426m

Abstract

A new dimeric acylphloroglucinol derivative, andinin A (1), was isolated from the underground plant parts of Hypericum andinum, along with three known dimeric acylphloroglucinols, uliginosin A (2), uliginosin B (3), and isouliginosin B (4). The structure of 1 was elucidated using 1D and 2D NMR and MS experiments and by comparison with previously reported data for Hypericum dimeric acylphloroglucinols. Andinin A (1) displayed antidepressant-like activity in a mouse forced-swimming test when administered orally at doses of 3, 10, and 30 mg/kg.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Animals
Antidepressive Agents* / chemistry
Antidepressive Agents* / isolation & purification
Antidepressive Agents* / pharmacology
Dose-Response Relationship, Drug
Hypericum / chemistry*
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peru
Phloroglucinol* / analogs & derivatives
Phloroglucinol* / chemistry
Phloroglucinol* / isolation & purification
Phloroglucinol* / pharmacology

Substances

Antidepressive Agents
andinin A
Phloroglucinol
uliginosin B