Abstract
A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group.
MeSH terms
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Acetaminophen / adverse effects
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Animals
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Antioxidants / metabolism
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Chemical and Drug Induced Liver Injury / drug therapy
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Chemical and Drug Induced Liver Injury / pathology
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Chemical and Drug Induced Liver Injury / prevention & control
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Disease Models, Animal
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Isoflavones / chemistry*
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Isoflavones / pharmacology*
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Lepidium sativum / chemistry*
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Liver / drug effects
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Liver / metabolism
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Liver / pathology
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Liver Function Tests
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Male
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oxidative Stress / drug effects
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Protective Agents / chemistry*
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Protective Agents / pharmacology*
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Rats
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Seeds / chemistry*
Substances
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Antioxidants
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Isoflavones
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Plant Extracts
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Protective Agents
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Acetaminophen