Insights into the U1 small nuclear ribonucleoprotein complex superfamily

J Guiro; D O'Reilly

doi:10.1002/wrna.1257

Insights into the U1 small nuclear ribonucleoprotein complex superfamily

Wiley Interdiscip Rev RNA. 2015 Jan-Feb;6(1):79-92. doi: 10.1002/wrna.1257. Epub 2014 Sep 26.

Authors

J Guiro¹, D O'Reilly

Affiliation

¹ Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil.

PMID: 25263988
DOI: 10.1002/wrna.1257

Abstract

The 164 bp U1 small nuclear (sn) RNA is one of the most abundant noncoding (nc) RNA in human cells, estimated to be in the region of 10(6) copies/cell. Although best known for its role in pre-messenger RNA (mRNA) splicing events, research over the past 20 years has revealed diverse functions of this ncRNA in mammalian cell types. Excellent reviews exist detailing the role of U1 snRNA in pre-mRNA splicing events. This review highlights what is currently known regarding the additional roles, snRNP composition, expression profiles, and the genomic organization of this ncRNA.

Publication types

Review

MeSH terms

Animals
Gene Expression Regulation
Humans
Mammals
RNA Precursors / metabolism*
RNA Processing, Post-Transcriptional*
Ribonucleoprotein, U1 Small Nuclear / genetics*
Ribonucleoprotein, U1 Small Nuclear / metabolism*

Substances

RNA Precursors
Ribonucleoprotein, U1 Small Nuclear