Abstract
Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acute Kidney Injury / epidemiology*
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Acute Kidney Injury / etiology
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Acute Kidney Injury / therapy
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Age of Onset
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Aged
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Aging / physiology*
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Animals
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Cardiovascular Diseases / epidemiology
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Cell Death
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Comorbidity
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Diabetic Nephropathies / epidemiology
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Disease Susceptibility
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Hemodynamics
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Humans
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Inflammation / physiopathology
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Ischemia / complications
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Ischemia / physiopathology
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Kidney / blood supply
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Kidney / drug effects
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Kidney / growth & development*
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Kidney Failure, Chronic / complications
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Kidney Failure, Chronic / epidemiology
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Kidney Failure, Chronic / physiopathology
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Mice
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Mice, Inbred C57BL
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Middle Aged
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Oxidative Stress
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Pharmacokinetics
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Prognosis
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Rats
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Rats, Inbred F344
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Regeneration
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Reperfusion Injury / complications
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Reperfusion Injury / physiopathology
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Xenobiotics / toxicity