A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging

Chem Commun (Camb). 2014 Nov 18;50(89):13833-6. doi: 10.1039/c4cc05539j.

Abstract

A lysosome-targeted fluorescent chemodosimeter, 1, was developed for monitoring endogenous and exogenous H2S by in vivo imaging of HeLa cells, D. melanogaster and C. elegans. In the tests of mutated C. elegans (SRP-6 nulls), chemodosimeter 1 could trace the accumulation of lysosome and lysosomal injury with a high resolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / metabolism*
  • Coumarins / chemistry
  • Coumarins / pharmacology*
  • Drosophila melanogaster / metabolism*
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / pharmacology*
  • HeLa Cells
  • Humans
  • Hydrogen Sulfide / metabolism*
  • Lysosomes / metabolism*
  • Optical Imaging

Substances

  • Coumarins
  • Fluorescent Dyes
  • Hydrogen Sulfide