Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan

Infect Genet Evol. 2014 Dec:28:125-9. doi: 10.1016/j.meegid.2014.09.019. Epub 2014 Sep 22.

Abstract

Human cosavirus (HCoSV) is a genus recently identified in the family Picornaviridae, which includes important pathogens in human health. The pathogenicity of HCoSV remains unclear. This study reports that an HCoSV strain, 10928/2012/JPN, was identified and collected from the stool sample of a child with acute gastroenteritis in Japan, with the detection rate of 0.16%. The patient was not co-infected with other common diarrhea-causal viruses, suggesting HCoSV as a causal pathogen in this pediatric patient. Phylogenetic and sequence analyses exhibited that the virus strain was classified as a new genotype in HCoSV A species, and this study is first to detect HCoSV in a clinical specimen collected in Japan. These results showed that surveillance of HCoSV is important for detecting viral agents in children with diarrhea, despite being the low detection rate.

Keywords: Child; Diarrhea; Genotype; Human cosavirus; Japan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Evolution, Molecular
  • Feces / virology
  • Gastroenteritis / virology*
  • Humans
  • Infant
  • Infant, Newborn
  • Japan
  • Phylogeny
  • Picornaviridae / classification*
  • Picornaviridae / genetics
  • Picornaviridae / isolation & purification*
  • Picornaviridae Infections / virology*
  • RNA, Viral / analysis

Substances

  • RNA, Viral