The potential application of personalized preventive research

Jpn J Clin Oncol. 2014 Nov;44(11):1017-24. doi: 10.1093/jjco/hyu135. Epub 2014 Sep 23.

Abstract

With increases in life expectancy, the focus has shifted to living a healthier, longer life. By concentrating on preventing diseases before occurrence, researchers aim to diminish the increasing gap in medical costs and health inequalities prevalent across many nations. Although we have entered an era of post-genomics, we are still in infancy in terms of personalized preventive research. Personalized preventive research has and will continue to improve with advancements in the use of biomarkers and risk assessment. More evidence based on well-designed epidemiologic studies is required to provide comprehensive preventive medical care based on genetic and non-genetic profile data. The realization of personalized preventive research requires building of evidence through appropriate methodology, verification of results through translational studies as well as development and application of prediction models.

Keywords: environmental medicine; epidemiology; personalized medicine; preventive medicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / prevention & control
  • Delivery of Health Care
  • Female
  • Genetic Counseling
  • Genomics
  • Health Care Costs
  • Humans
  • Neoplasms / genetics
  • Neoplasms / prevention & control*
  • Precision Medicine*
  • Primary Prevention*
  • Research*
  • Risk Assessment
  • Socioeconomic Factors