C(sp³)-¹⁸F bond formation by transition-metal-based [¹⁸F]fluorination

Steven H Liang; Neil Vasdev

doi:10.1002/anie.201407065

C(sp³)-¹⁸F bond formation by transition-metal-based [¹⁸F]fluorination

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11416-8. doi: 10.1002/anie.201407065. Epub 2014 Sep 22.

Authors

Steven H Liang¹, Neil Vasdev

Affiliation

¹ Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, 55 Fruit St., White 427, Boston, MA 02114 (USA). Liang.Steven@mgh.harvard.edu.

Abstract

Recent advances in aliphatic radiofluorinations enabled by transition metals, specifically Co- and Mn-salen complexes, have been unveiled. These new approaches operate in a unique way that obviates the need of highly activated substrates for radiolabeling and offers a new synthetic strategy to prepare ¹⁸F-labeled radiotracers.

Keywords: Fluorine-18; imaging agents; positron emission tomography; radiochemistry; transition metals.

MeSH terms

Fluorine Radioisotopes / chemistry*
Positron-Emission Tomography
Transition Elements / chemistry*

Substances

Fluorine Radioisotopes
Transition Elements

Grants and funding

K01 DA038000/DA/NIDA NIH HHS/United States