Overgrowth syndromes with complex vascular anomalies

Wibke Uller; Steven J Fishman; Ahmad I Alomari

doi:10.1053/j.sempedsurg.2014.06.013

Overgrowth syndromes with complex vascular anomalies

Semin Pediatr Surg. 2014 Aug;23(4):208-15. doi: 10.1053/j.sempedsurg.2014.06.013. Epub 2014 Jun 19.

Authors

Wibke Uller¹, Steven J Fishman², Ahmad I Alomari³

Affiliations

¹ Vascular Anomalies Center, Boston Children׳s Hospital and Harvard Medical School, Boston, Massachusetts; Division of Vascular and Interventional Radiology, Boston Children׳s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115.
² Vascular Anomalies Center, Boston Children׳s Hospital and Harvard Medical School, Boston, Massachusetts; Department of Surgery, Boston Children׳s Hospital and Harvard Medical School, Boston, Massachusetts.
³ Vascular Anomalies Center, Boston Children׳s Hospital and Harvard Medical School, Boston, Massachusetts; Division of Vascular and Interventional Radiology, Boston Children׳s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115. Electronic address: Ahmad.Alomari@childrens.harvard.edu.

PMID: 25241100
DOI: 10.1053/j.sempedsurg.2014.06.013

Abstract

Management of overgrowth syndromes with complex vascular anomalies is challenging. Careful analysis of the various clinical features by an interdisciplinary team of physicians experienced in this field is paramount to proper diagnostic and therapeutic approaches. In this article, we focus on the spectrum of the clinical presentation and the management strategies of the most common overgrowth syndromes with complex vascular anomalies.

Keywords: CLOVES; FAVA; Klippel–Trenaunay syndrome; Overgrowth syndromes; Vascular anomalies; Vascular malformations.

Publication types

Review

MeSH terms

Hamartoma Syndrome, Multiple* / genetics
Hamartoma Syndrome, Multiple* / pathology
Hamartoma Syndrome, Multiple* / therapy
Humans
Klippel-Trenaunay-Weber Syndrome* / genetics
Klippel-Trenaunay-Weber Syndrome* / pathology
Klippel-Trenaunay-Weber Syndrome* / therapy
Lipoma* / genetics
Lipoma* / pathology
Lipoma* / therapy
Musculoskeletal Abnormalities* / genetics
Musculoskeletal Abnormalities* / pathology
Musculoskeletal Abnormalities* / therapy
Nevus* / genetics
Nevus* / pathology
Nevus* / therapy
Sturge-Weber Syndrome* / genetics
Sturge-Weber Syndrome* / pathology
Sturge-Weber Syndrome* / therapy
Vascular Malformations* / genetics
Vascular Malformations* / pathology
Vascular Malformations* / therapy

Supplementary concepts

Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi