Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp

Yung-Shun Juan; Chien-Chih Lee; Chia-Wei Tsao; Mei-Chin Lu; Mohamed El-Shazly; Huei-Chuan Shih; Yu-Cheng Chen; Yang-Chang Wu; Jui-Hsin Su

doi:10.3390/ijms150916511

Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp

Int J Mol Sci. 2014 Sep 18;15(9):16511-21. doi: 10.3390/ijms150916511.

Authors

Yung-Shun Juan¹, Chien-Chih Lee², Chia-Wei Tsao³, Mei-Chin Lu⁴, Mohamed El-Shazly⁵, Huei-Chuan Shih⁶, Yu-Cheng Chen⁷, Yang-Chang Wu⁸, Jui-Hsin Su⁹

Affiliations

¹ Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan. juanuro@gmail.com.
² Epigenome Research Center, Department of Laboratory Medicine, China Medical University Hospital, Taichung 404, Taiwan. insect@hotmail.com.tw.
³ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. gaway4297@yahoo.com.tw.
⁴ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
⁵ Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt. elshazly444@googlemail.com.
⁶ Department of Nursing, Meiho University, Pingtung 912, Taiwan. x00002213@meiho.edu.tw.
⁷ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. j520c@hotmail.com.
⁸ Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan. yachwu@mail.cmu.edu.tw.
⁹ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.

Abstract

The sponge Petrosia sp. yielded five polyacetylenic compounds (1-5), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 1-5 exhibited significant cytotoxic activity against a limited panel of cancer cell lines.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / pathology
Animals
Breast Neoplasms / pathology
Cell Line, Tumor
Colonic Neoplasms / pathology
Drug Screening Assays, Antitumor
Female
Humans
Leukemia / pathology
Male
Molecular Structure
Petrosia / chemistry*
Polyynes / chemistry
Polyynes / isolation & purification*
Polyynes / pharmacology
Prostatic Neoplasms / pathology

Substances

Polyynes