Plague's partners in crime

Kimberly M Davis; Ralph R Isberg

doi:10.1016/j.immuni.2014.09.003

Plague's partners in crime

Immunity. 2014 Sep 18;41(3):347-349. doi: 10.1016/j.immuni.2014.09.003.

Authors

Kimberly M Davis¹, Ralph R Isberg²

Affiliations

¹ Howard Hughes Medical Institute, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.
² Howard Hughes Medical Institute, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA. Electronic address: ralph.isberg@tufts.edu.

PMID: 25238090
DOI: 10.1016/j.immuni.2014.09.003

Abstract

The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopathy.

Publication types

Comment

MeSH terms

Animals
Female
Lymph Nodes / pathology*
Lysophospholipids / genetics*
Plague / pathology*
Receptors, Lysosphingolipid / immunology*
Sphingosine / analogs & derivatives*
Sphingosine / genetics
Yersinia pestis / pathogenicity*

Substances

Lysophospholipids
Receptors, Lysosphingolipid
sphingosine 1-phosphate
Sphingosine