Synthesis of methyl propanoate by Baeyer-Villiger monooxygenases

Hugo L van Beek; Remko T Winter; Graham R Eastham; Marco W Fraaije

doi:10.1039/c4cc06489e

Synthesis of methyl propanoate by Baeyer-Villiger monooxygenases

Chem Commun (Camb). 2014 Nov 7;50(86):13034-6. doi: 10.1039/c4cc06489e.

Authors

Hugo L van Beek¹, Remko T Winter, Graham R Eastham, Marco W Fraaije

Affiliation

¹ Molecular Enzymology Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Netherlands. m.w.fraaije@rug.nl.

PMID: 25227202
DOI: 10.1039/c4cc06489e

Abstract

Methyl propanoate is an important precursor for polymethyl methacrylates. The use of a Baeyer-Villiger monooxygenase (BVMO) to produce this compound was investigated. Several BVMOs were identified that produce the chemically non-preferred product methyl propanoate in addition to the normal product ethyl acetate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter / enzymology
Biocatalysis
Ketones / chemistry
Ketones / metabolism
Mixed Function Oxygenases / chemistry
Mixed Function Oxygenases / classification
Mixed Function Oxygenases / metabolism*
Oxidation-Reduction
Phylogeny
Propionates / chemistry
Propionates / metabolism*
Rhodococcus / enzymology
Substrate Specificity

Substances

Ketones
Propionates
Mixed Function Oxygenases