Leptin and its receptors

Nobuhiro Wada; Satoshi Hirako; Fumiko Takenoya; Haruaki Kageyama; Mai Okabe; Seiji Shioda

doi:10.1016/j.jchemneu.2014.09.002

Leptin and its receptors

J Chem Neuroanat. 2014 Nov:61-62:191-9. doi: 10.1016/j.jchemneu.2014.09.002. Epub 2014 Sep 16.

Authors

Nobuhiro Wada¹, Satoshi Hirako¹, Fumiko Takenoya², Haruaki Kageyama³, Mai Okabe⁴, Seiji Shioda⁵

Affiliations

¹ Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8555, Japan.
² Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8555, Japan; Department of Physical Education, Hoshi University School of Pharmacy and Pharmaceutical Science, Tokyo 142-8501, Japan.
³ Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8555, Japan; Department of Nutrition, Faculty of Health Care, Kiryu University, 606-7 Kasakakecho Azami, Midori City 379-2392, Gunma, Japan.
⁴ Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8555, Japan; Tokyo Shokuryo Dietitian Academy, Tokyo 154-0001, Japan.
⁵ Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8555, Japan. Electronic address: shioda@med.showa-u.ac.jp.

PMID: 25218975
DOI: 10.1016/j.jchemneu.2014.09.002

Abstract

Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf). LepRb, in particular, is expressed in several brain nuclei, including the arcuate nucleus, the paraventricular nucleus, and the dorsomedial, lateral and ventromedial regions of the hypothalamus. LepRb is also co-expressed with several neuropeptides, including proopiomelanocortin, neuropeptide Y, galanin, galanin-like peptide, gonadotropin-releasing hormone, tyrosine hydroxylase and neuropeptide W. Functionally, LepRb induces activation of the JAK2/ERK, /STAT3, /STAT5 and IRS/PI3 kinase signaling cascades, which are important for the regulation of energy homeostasis and appetite in mammals. In this review, we discuss the structure, genetics and distribution of the leptin receptors, and their role in cell signaling mechanisms.

Keywords: JAK-STAT; Leptin; Leptin receptor; Neuropeptide; db Gene; ob Gene.

Publication types

Review

MeSH terms

Animals
Humans
Leptin*
Receptors, Leptin*

Substances

Leptin
Receptors, Leptin