Differential regulation of germline apoptosis in response to meiotic checkpoint activation

Genetics. 2014 Nov;198(3):995-1000. doi: 10.1534/genetics.114.170241. Epub 2014 Sep 11.

Abstract

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

Keywords: DNA damage; apoptosis; checkpoint; recombination; synapsis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis* / genetics
  • Caenorhabditis elegans / cytology*
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Cell Cycle Checkpoints* / genetics
  • Chromosome Pairing / genetics
  • Germ Cells / cytology*
  • Meiosis* / genetics
  • Mutation / genetics
  • Regulatory Sequences, Nucleic Acid / genetics
  • Transcription, Genetic

Substances

  • Caenorhabditis elegans Proteins