Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

Subhi A Al-Jibori; Ghassan H Al-Jibori; Lamaan J Al-Hayaly; Christoph Wagner; Harry Schmidt; Suna Timur; F Baris Barlas; Elif Subasi; Shishir Ghosh; Graeme Hogarth

doi:10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

J Inorg Biochem. 2014 Dec:141:55-57. doi: 10.1016/j.jinorgbio.2014.07.017. Epub 2014 Aug 1.

Authors

Affiliations

¹ Department of Chemistry, College of Science, University of Tikrit, Tikrit, Iraq. Electronic address: subhi_aljibori@yahoo.com.
² Department of Chemistry, College of Science, University of Tikrit, Tikrit, Iraq.
³ Department of Chemistry, College of Pharmacy, Hawler University of Medicine, Erbil, Iraq.
⁴ Institut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle, Germany.
⁵ Department of Biochemistry, Ege University, Faculty of Science, 35100 Bornova, Izmir, Turkey.
⁶ Department of Chemistry, Faculty of Science, Dokuz Eylul University, 35160 Buca-Tinaztepe, Izmir, Turkey.
⁷ Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
⁸ Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK. Electronic address: graeme.hogarth@kcl.ac.uk.

PMID: 25216367
DOI: 10.1016/j.jinorgbio.2014.07.017

Abstract

The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2] x H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.

Keywords: Ammine; Anti-cancer; Cisplatin; Saccharinate; Thiosaccharinate; X-ray structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Coordination Complexes / chemical synthesis*
Coordination Complexes / pharmacology
Crystallography, X-Ray
Humans
Methotrexate / pharmacology
Organoplatinum Compounds / chemical synthesis*
Organoplatinum Compounds / pharmacology
Saccharin / analogs & derivatives
Saccharin / chemical synthesis*
Saccharin / pharmacology
Structure-Activity Relationship
Sweetening Agents / chemical synthesis*
Sweetening Agents / pharmacology

Substances

Antineoplastic Agents
Coordination Complexes
Organoplatinum Compounds
Sweetening Agents
Saccharin
Methotrexate