Association of ALOX5AP with ischemic stroke in eastern Chinese

Yao Wang; Gan-Nan Wang; Hao Sun; Chen Chen; Hang Xiao; Jin-Song Zhang

doi:10.5847/wjem.j.issn.1920-8642.2012.02.005

Association of ALOX5AP with ischemic stroke in eastern Chinese

World J Emerg Med. 2012;3(2):108-13. doi: 10.5847/wjem.j.issn.1920-8642.2012.02.005.

Authors

Yao Wang¹, Gan-Nan Wang¹, Hao Sun¹, Chen Chen², Hang Xiao³, Jin-Song Zhang¹

Affiliations

¹ Department of Emergency Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
² Jiangsu Province Center for Disease Control, Nanjing, China.
³ Laboratory of Neurotoxicology, School of Public Health, Nanjing Medical University, Nanjing, China.

PMID: 25215047
PMCID: PMC4129791
DOI: 10.5847/wjem.j.issn.1920-8642.2012.02.005

Abstract

Background: 5-lipoxygenase protein (ALOX5AP) has been recognized as a susceptibility gene for stroke and coronary artery diseases. The present study was to explore the role of this gene in the eastern Chinese patients with ischemic stroke.

Methods: Using a case-control design, we studied 658 patients with ischemic stroke and 704 unrelated population-based controls who were age- and sex-matched. The 658 patients were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Two single-nucleotide polymorphisms (SNPs) covering ALOX5AP were genotyped.

Results: The genotype frequencies of TG of the SNPs rs17222919 located in the promoter of the ALOX5AP gene were significantly higher in patients with ischemic stroke than in controls (OR (*)=1.34, 95%CI(*)=1.02-1.75), especially in patients with ischemic stroke caused by small-artery occlusion (SAO) (OR (*)=1.40, 95%CI(*)=1.02-1.93). Meanwhile, the genotype frequencies of TG and TG/GG were higher in female patients than in the controls. After specification, the genotype frequencies of TG and TG/GG were higher in the patients than in controls with hypertension. The genotype frequencies of AG and AG/GG of the SNPs rs9579646 located in the intron of the ALOX5AP gene were higher in the controls than in the patients. After specification, the genotype frequencies of TG were higher in the controls than patients without hypertension.

Conclusion: The present study suggests that sequence variants in the ALOX5AP gene are significantly associated with ischemic stroke.

Keywords: 5-lipoxygenase activating protein (ALOX5AP); Ischemic stroke; Leukotrienes (LTs); Single nucleotide polymorphisms (SNPs); Trial of Org 10172 in Acute Stroke Treatment (TOAST).