Polyelectrolyte Films Boost Progenitor Cell Differentiation into Endothelium-like Monolayers

Nicolas Berthelemy; Halima Kerdjoudj; Caroline Gaucher; Pierre Schaaf; Jean-François Stoltz; Patrick Lacolley; Jean-Claude Voegel; Patrick Menu

doi:10.1002/adma.200702418

Polyelectrolyte Films Boost Progenitor Cell Differentiation into Endothelium-like Monolayers

Adv Mater. 2008 Jul 17;20(14):2674-8. doi: 10.1002/adma.200702418. Epub 2008 Jun 2.

Authors

Nicolas Berthelemy¹, Halima Kerdjoudj, Caroline Gaucher, Pierre Schaaf, Jean-François Stoltz, Patrick Lacolley, Jean-Claude Voegel, Patrick Menu

Affiliation

¹ Group of Bioengineering (LEMTA-UMR CNRS 7563) UHP-Nancy 1, Faculté de Médecine 9, avenue de la forêt de Haye 54505 Vandoeuvre-lès-Nancy (France).

PMID: 25213888
DOI: 10.1002/adma.200702418

Abstract

Rapid differentiation of endothelial progenitor cells (EPCs) into confluent mature endothelial cells is important in tissue engineering for the design of autologous, nonthrombotic, vascular grafts. A new method based on EPC culture on poly(sodium-4- styrene-sulfonate)/poly(allylamine hydrochloride), that is, polyelectrolyte-multilayer-coated substrates, reduces the time from two months to two weeks.

Keywords: biomedical applications; cells; multilayer films; polyelectrolytes; tissue engineering.