Inhibition of angiogenesis by antioxidant micelles

Adv Healthc Mater. 2015 Mar 11;4(4):569-75. doi: 10.1002/adhm.201400249. Epub 2014 Sep 11.

Abstract

Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

Keywords: angiogenesis; antioxidants; drug delivery; micelles; oxidation.

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Animals
  • Antioxidants / therapeutic use*
  • Catechols / therapeutic use
  • Cell Death / drug effects
  • Chickens
  • Chorioallantoic Membrane / drug effects
  • Chorioallantoic Membrane / metabolism
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Indoles / chemical synthesis
  • Indoles / chemistry
  • Indoles / toxicity
  • Micelles*
  • Neovascularization, Pathologic / drug therapy*
  • Oxidation-Reduction
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / toxicity
  • Polymers / chemical synthesis
  • Polymers / chemistry
  • Polymers / toxicity
  • Proton Magnetic Resonance Spectroscopy
  • Reactive Oxygen Species / metabolism

Substances

  • Angiogenesis Inhibitors
  • Antioxidants
  • Catechols
  • Indoles
  • Micelles
  • Polymers
  • Reactive Oxygen Species
  • polydopamine
  • Polyethylene Glycols
  • catechol