An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis

Cytokine. 2015 Jan;71(1):16-21. doi: 10.1016/j.cyto.2014.08.001. Epub 2014 Sep 16.

Abstract

Infective endocarditis (IE) is an inflammatory condition of the lining of the heart chambers and valves, which is generally caused by bacteria. Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells (TREMs) are key effectors of the innate system that play a significant role in the recognition of infectious agents, particularly, bacteria. We hypothesised that inherited variation in TLR and TREM-1 genes may affect individual susceptibility to IE. The distribution of genotypes and alleles of the TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), TLR6 (rs3775073, rs5743810), and TREM-1 (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, rs2234237) gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that C/C genotype of the rs3775073 polymorphism within TLR6 gene was associated with a decreased risk of IE (OR=0.51, 95% CI=0.26-0.97, P=0.032) according to the recessive model; however, we observed no association between the other investigated SNPs within TLR and TREM-1 genes and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE.

Keywords: Infective endocarditis; Innate immunity; Single nucleotide polymorphisms; TREM-1; Toll-like receptors.

MeSH terms

  • Alleles
  • Endocarditis / genetics*
  • Endocarditis / immunology
  • Endocarditis / mortality
  • Female
  • Genetic Association Studies / statistics & numerical data
  • Genetic Predisposition to Disease*
  • Genotype
  • Healthy Volunteers
  • Humans
  • Immunity, Innate / genetics
  • Male
  • Membrane Glycoproteins / genetics*
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Receptors, Immunologic / genetics*
  • Toll-Like Receptor 6 / genetics*
  • Toll-Like Receptors / genetics*
  • Triggering Receptor Expressed on Myeloid Cells-1

Substances

  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • Toll-Like Receptor 6
  • Toll-Like Receptors
  • Triggering Receptor Expressed on Myeloid Cells-1