NMD: nonsense-mediated defense

Cell Host Microbe. 2014 Sep 10;16(3):273-5. doi: 10.1016/j.chom.2014.08.015.

Abstract

Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alphavirus Infections / virology*
  • Arabidopsis / genetics*
  • Arabidopsis / immunology*
  • Carrier Proteins / metabolism*
  • Humans
  • Nonsense Mediated mRNA Decay*
  • Plant Diseases / virology*
  • Potexvirus / genetics*
  • Pseudomonas syringae / physiology*
  • RNA Helicases
  • RNA, Viral / genetics*
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / immunology*
  • Semliki forest virus / physiology*
  • Trans-Activators / metabolism*
  • Virus Replication*

Substances

  • Carrier Proteins
  • RNA, Viral
  • Receptors, Immunologic
  • SMG5 protein, human
  • SMG7 protein, human
  • Trans-Activators
  • RNA Helicases
  • UPF1 protein, human