An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative

Arun K Ghosh; Kalapala Venkateswara Rao; Siddhartha Akasapu

doi:10.1016/j.tetlet.2014.07.077

An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative

Tetrahedron Lett. 2014 Sep 10;55(37):5191-5194. doi: 10.1016/j.tetlet.2014.07.077.

Authors

Arun K Ghosh¹, Kalapala Venkateswara Rao¹, Siddhartha Akasapu¹

Affiliation

¹ Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.

Abstract

Aetheramides A and B are very potent anti-HIV agents. An enantioselective synthesis of a MEM-protected aetheramide A derivative is described. The synthesis was accomplished in a convergent and stereoselective manner. The key reactions involved asymmetric dihydroxylation, asymmetric allylation, asymmetric syn-aldol reactions and asymmetric hydrogenation.

Keywords: Aetheramides; Anti-HIV; Anticancer; Asymmetric synthesis; Natural product.

Abstract

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