Quality control: H2A.X links to better iPSCs

Yawei Gao; Shaorong Gao

doi:10.1016/j.stem.2014.08.011

Quality control: H2A.X links to better iPSCs

Cell Stem Cell. 2014 Sep 4;15(3):259-260. doi: 10.1016/j.stem.2014.08.011.

Authors

Yawei Gao¹, Shaorong Gao²

Affiliations

¹ School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
² School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address: gaoshaorong@tongji.edu.cn.

PMID: 25192458
DOI: 10.1016/j.stem.2014.08.011

Abstract

Incorporating induced pluripotent stem cell (iPSC) technology in regenerative medicine requires better methods for defining and obtaining high-quality lines. Two papers in this issue of Cell Stem Cell (Buganim et al., 2014; Wu et al., 2014) now show that H2A.X deposition can serve as a functional epigenetic marker for distinguishing the quality of iPSCs, thus providing insights for better reprogramming methods.