Abstract
Two new marine-derived caryophyllene-type sesquiterpenoids, rumphellols A and B (1 and 2), were obtained from the gorgonian coral, Rumphella antipathies, collected off the waters of Taiwan. Although caryophyllene-type sesquiterpenes are rarely found in marine organisms, compounds of this type could be principal components of R. antipathies. The structures of new Compounds 1 and 2 were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Caryophyllene 1 and 2 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cell Extracts / chemistry*
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Cell Extracts / pharmacology
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Humans
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Neutrophils / drug effects
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Neutrophils / enzymology
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Pancreatic Elastase / metabolism
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Polycyclic Sesquiterpenes
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Sesquiterpenes / chemistry*
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Sesquiterpenes / pharmacology
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Sesterterpenes / chemistry*
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Sesterterpenes / pharmacology
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Superoxides / metabolism
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cell Extracts
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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Sesterterpenes
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rumphellol A
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rumphellol B
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Superoxides
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caryophyllene
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Pancreatic Elastase