Constituents of Vigna angularis and their in vitro anti-inflammatory activity

Phytochemistry. 2014 Nov:107:111-8. doi: 10.1016/j.phytochem.2014.08.011. Epub 2014 Sep 1.

Abstract

Nine non-phenolic compounds, including four furanylmethyl glycosides, angularides A-D, one ent-kaurane diterpene glycoside, angularin A, and four triterpenoid saponins, angulasaponins A-D, were isolated from seeds of Vigna angularis, together with eight known compounds. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic analysis as well as chemical methods. Angularin A, angulasaponins A-C, and azukisaponins III and VI showed inhibition of nitric oxide production in LPS-activated RAW264.7 macrophages, with IC50 values ranging from 13μM to 24μM.

Keywords: Anti-inflammatory activity; Furanylmethyl glycosides; Leguminosae; Triterpene saponins; Vigna angularis; ent-Kaurane diterpene glycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology*
  • Diterpenes, Kaurane / chemistry
  • Diterpenes, Kaurane / isolation & purification*
  • Diterpenes, Kaurane / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Fabaceae / chemistry*
  • In Vitro Techniques
  • Inhibitory Concentration 50
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Mice
  • Molecular Structure
  • Nitric Oxide / biosynthesis
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology*
  • Seeds / chemistry

Substances

  • Anti-Inflammatory Agents
  • Diterpenes, Kaurane
  • Drugs, Chinese Herbal
  • Lipopolysaccharides
  • Saponins
  • angularin A
  • Nitric Oxide