Intraperitoneal insulin therapy for a patient with type 1 diabetes with insulin injection site inflammation

BMJ Case Rep. 2014 Aug 21:2014:bcr2014205278. doi: 10.1136/bcr-2014-205278.

Abstract

A 36-year-old man with type 1 diabetes developed skin inflammation at the site of subcutaneous insulin injection after 10 years of basal bolus subcutaneous insulin therapy. This inflammation led to poor insulin absorption, poorly controlled blood glucose and subsequently to ketoacidosis. The problem persisted despite a trial of continuous subcutaneous insulin infusion. The patient went on to be treated with continuous intraperitoneal insulin infusion. Three months after the procedure, he was achieving good glucose control and was able to resume his normal life, with the only complication being an episode of cellulitis surrounding the port site.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Cellulitis / etiology
  • Dermatitis / etiology*
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetic Ketoacidosis / etiology
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Hypoglycemic Agents / pharmacokinetics
  • Infusions, Parenteral / adverse effects
  • Injections, Subcutaneous / adverse effects*
  • Insulin / administration & dosage*
  • Insulin / pharmacokinetics
  • Male
  • Self Care
  • Skin Absorption

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin