Polymeric anti-HIV therapeutics

Macromol Biosci. 2015 Jan;15(1):9-35. doi: 10.1002/mabi.201400298. Epub 2014 Sep 3.

Abstract

The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti-HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC-SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti-HIV therapeutics.

Keywords: HIV polymer therapeutics; antiviral; inhibitor; microbicide; polyvalency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Retroviral Agents / chemistry
  • Anti-Retroviral Agents / therapeutic use*
  • Cell Adhesion Molecules / antagonists & inhibitors*
  • HIV Infections / prevention & control*
  • HIV Infections / transmission*
  • HIV-1 / physiology*
  • Humans
  • Integrase Inhibitors / therapeutic use
  • Lectins, C-Type / antagonists & inhibitors*
  • Molecular Structure
  • Polymers / chemistry
  • Polymers / therapeutic use*
  • Receptors, Cell Surface / antagonists & inhibitors*
  • Reverse Transcription / drug effects
  • Virus Internalization / drug effects

Substances

  • Anti-Retroviral Agents
  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Integrase Inhibitors
  • Lectins, C-Type
  • Polymers
  • Receptors, Cell Surface