rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population

PLoS One. 2014 Sep 3;9(9):e104525. doi: 10.1371/journal.pone.0104525. eCollection 2014.

Abstract

Ankylosing spondylitis (AS) is a highly familial rheumatic disorder and is considered as a chronic inflammatory disease. Genetic factors are involved in the pathogenesis of AS. To identify genes which render people susceptible to AS in a Taiwanese population, we selected six single-nucleotide polymorphisms (SNPs) from previous genome-wide association studies (GWASs) which were associated with AS in European descendants and Han Chinese. To assess whether the six SNPs contributed to AS susceptibility and severity in Taiwanese population, 475 AS patients fulfilling the modified New York Criteria and 527 healthy subjects were recruited. We found that rs10865331 was significantly associated with AS susceptibility and with Bath AS Function Index (BASFI). The AA and AG genotypes of rs10865331 were also significantly associated with a higher erythrocyte sedimentation rate. Our findings provided evidence that rs10865331 is associated AS susceptibility and with disease activity (BASFI) in a Taiwanese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People*
  • Blood Sedimentation
  • Case-Control Studies
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Severity of Illness Index
  • Spondylitis, Ankylosing / ethnology*
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / pathology
  • Taiwan / epidemiology
  • White People

Grants and funding

This work was supported by the funding from an Excellence for Cancer Research Center grant, Department of Health, Executive Yuan, Taiwan, R.O.C. (DOH102-TD-C-111-002) and grants from the National Science Council, Taiwan, ROC (NSC101-2628-B038-001-MY2; NSC101-2320-B038-029-MY3). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.