Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia

Hypertens Pregnancy. 2015 Feb;34(1):17-23. doi: 10.3109/10641955.2014.951490. Epub 2014 Sep 2.

Abstract

Objectives: To investigate into an association between circulating levels of vascular factors (VF: ACE, eNOS, PlGF and VEGF) and impaired fetal growth measured as a small for gestational age newborn (SGA) in women with gestational hypertension/preeclampsia.

Methods: A prospective observational trial in 46 patients in singleton pregnancies. Concentrations of VF were compared between participants who delivered SGA versus non-SGA newborns.

Results: only low levels of ACE were associated with significantly increased risk for SGA (for a cut-off value, LR: 1.4-3.6).

Conclusions: Circulating levels of VF are not sufficient predictors of SGA in pregnancies complicated by gestational hypertension/preeclampsia.

Keywords: Angiogenic factors; IUGR; fetal growth; hypertensive pregnancy; placenta.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Female
  • Fetal Growth Retardation / blood*
  • Fetal Growth Retardation / etiology
  • Humans
  • Infant, Small for Gestational Age
  • Nitric Oxide Synthase Type III / blood*
  • Peptidyl-Dipeptidase A / blood*
  • Placenta Growth Factor
  • Pre-Eclampsia / blood*
  • Pregnancy
  • Pregnancy Proteins / blood*
  • Prospective Studies
  • Vascular Endothelial Growth Factor A / blood*

Substances

  • Biomarkers
  • PGF protein, human
  • Pregnancy Proteins
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Placenta Growth Factor
  • NOS3 protein, human
  • Nitric Oxide Synthase Type III
  • ACE protein, human
  • Peptidyl-Dipeptidase A