Objectives: To investigate into an association between circulating levels of vascular factors (VF: ACE, eNOS, PlGF and VEGF) and impaired fetal growth measured as a small for gestational age newborn (SGA) in women with gestational hypertension/preeclampsia.
Methods: A prospective observational trial in 46 patients in singleton pregnancies. Concentrations of VF were compared between participants who delivered SGA versus non-SGA newborns.
Results: only low levels of ACE were associated with significantly increased risk for SGA (for a cut-off value, LR: 1.4-3.6).
Conclusions: Circulating levels of VF are not sufficient predictors of SGA in pregnancies complicated by gestational hypertension/preeclampsia.
Keywords: Angiogenic factors; IUGR; fetal growth; hypertensive pregnancy; placenta.