Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging

Adv Mater. 2014 Oct 22;26(39):6761-6766. doi: 10.1002/adma.201402964. Epub 2014 Sep 1.

Abstract

Nanoprobes for MRI and optical imaging are demonstrated. Gd@C-dots possess strong fluorescence and can effectively enhance signals on T1 -weighted MR images. The nanoprobes have low toxicity, and, despite a relatively large size, can be efficiently excreted by renal clearance from the host after systemic injection.

Keywords: MRI; T1 contrast agent; carbonaceous dots; gadolinium; renal clearance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Capsules
  • Carbon / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Contrast Media / chemistry
  • Contrast Media / pharmacokinetics
  • Contrast Media / toxicity
  • Drug Stability
  • Gadolinium / chemistry*
  • Gadolinium / pharmacokinetics
  • Gadolinium / toxicity
  • Humans
  • Kidney / metabolism*
  • Ligands
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Nanoparticles / chemistry*
  • Oligopeptides / chemistry

Substances

  • Capsules
  • Contrast Media
  • Ligands
  • Oligopeptides
  • Carbon
  • arginyl-glycyl-aspartic acid
  • Gadolinium