Abstract
Nanoprobes for MRI and optical imaging are demonstrated. Gd@C-dots possess strong fluorescence and can effectively enhance signals on T1 -weighted MR images. The nanoprobes have low toxicity, and, despite a relatively large size, can be efficiently excreted by renal clearance from the host after systemic injection.
Keywords:
MRI; T1 contrast agent; carbonaceous dots; gadolinium; renal clearance.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Capsules
-
Carbon / chemistry*
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Contrast Media / chemistry
-
Contrast Media / pharmacokinetics
-
Contrast Media / toxicity
-
Drug Stability
-
Gadolinium / chemistry*
-
Gadolinium / pharmacokinetics
-
Gadolinium / toxicity
-
Humans
-
Kidney / metabolism*
-
Ligands
-
Magnetic Resonance Imaging / methods*
-
Mice
-
Nanoparticles / chemistry*
-
Oligopeptides / chemistry
Substances
-
Capsules
-
Contrast Media
-
Ligands
-
Oligopeptides
-
Carbon
-
arginyl-glycyl-aspartic acid
-
Gadolinium