Surface decorated poly(ester-ether-urethane)s nanoparticles: a versatile approach towards clinical translation

Int J Pharm. 2014 Nov 20;475(1-2):523-35. doi: 10.1016/j.ijpharm.2014.08.065. Epub 2014 Aug 29.

Abstract

Poly(ester-ether-urethane)s copolymers are a resourceful class of biopolymers for the preparation of nanocarriers for drug delivery applications. However, a simple clinical translation for this synthetic material with biological and quality features is still needed. In this view, poly(ε-caprolactone)-co-poly(ethylene glycol) copolymers were synthesized as semi-bulk pilot (Kg) scale under mild conditions in absence of catalyst, bearing functional termini such as fluorescein tag and anticancer targeting moieties. The obtained materials were processed into surface decorated paclitaxel (PTX) loaded nanoparticles (NPs). The NPs were fully characterized in vitro and in vivo biodistribution in healthy mice evidenced no sign of toxicity and lower levels of PTX in lung and spleen, compared to clinically applied PTX dosage form.

Keywords: Folic acid (PubChem CID:6037); Nanomedicine; Paclitaxel (PubChem CID: 36314); Poly(ester ether urethane)s; Surface charge; Targeted drug delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacokinetics
  • BALB 3T3 Cells
  • Mice
  • Nanoparticles / chemistry*
  • Paclitaxel / administration & dosage
  • Paclitaxel / chemistry*
  • Paclitaxel / pharmacokinetics
  • Polyesters / chemistry
  • Polyethylene Glycols
  • Polyurethanes
  • Tissue Distribution

Substances

  • Antineoplastic Agents, Phytogenic
  • Polyesters
  • Polyurethanes
  • microthane foam
  • polycaprolactone
  • Polyethylene Glycols
  • Paclitaxel