Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas

Louise E Karagiannidis; Cally J E Haynes; Katie J Holder; Isabelle L Kirby; Stephen J Moore; Neil J Wells; Philip A Gale

doi:10.1039/c4cc05519e

Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas

Chem Commun (Camb). 2014 Oct 18;50(81):12050-3. doi: 10.1039/c4cc05519e.

Authors

Louise E Karagiannidis¹, Cally J E Haynes, Katie J Holder, Isabelle L Kirby, Stephen J Moore, Neil J Wells, Philip A Gale

Affiliation

¹ Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. philip.gale@soton.ac.uk.

PMID: 25178589
DOI: 10.1039/c4cc05519e

Abstract

Simple, highly fluorinated receptors are shown to function as highly effective transmembrane anion antiporters with the most active transporters rivalling the transport efficacy of natural anion transporter prodigiosin for bicarbonate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anion Transport Proteins / chemistry
Anion Transport Proteins / metabolism*
Bicarbonates / chemistry
Bicarbonates / metabolism
Crystallography, X-Ray
Liposomes / chemistry
Liposomes / metabolism
Molecular Conformation
Phenylenediamines / chemistry*
Prodigiosin / chemistry
Prodigiosin / metabolism
Thiourea / chemistry
Thiourea / metabolism
Urea / chemistry
Urea / metabolism*

Substances

Anion Transport Proteins
Bicarbonates
Liposomes
Phenylenediamines
Urea
Thiourea
Prodigiosin