[Synthesis of phosphobetaine--a derivative of long-chain tertiary aliphatic amine with epichlorohydrin]

Acta Pol Pharm. 1989;46(4):337-42.
[Article in Polish]

Abstract

Synthesis of a new surface active agent, a phosphobetaine derivative of tertiary amines with C12-22 long chains and sodium 3-chloro-2-hydroxypropyl phosphate has been elaborated. The reactants were applied at the molar ratio of 1:1.3. The obtained compounds was found to possess high surfactant and antimicrobial activities.

MeSH terms

  • Amines / chemical synthesis
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemical synthesis
  • Anti-Infective Agents / pharmacology*
  • Arthrodermataceae / drug effects*
  • Betaine / analogs & derivatives*
  • Betaine / chemical synthesis
  • Betaine / pharmacology
  • Epichlorohydrin / chemical synthesis
  • In Vitro Techniques
  • Pseudomonas aeruginosa / drug effects*
  • Staphylococcus aureus / drug effects*
  • Surface-Active Agents

Substances

  • Amines
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Surface-Active Agents
  • Epichlorohydrin
  • Betaine