Tissue engineering strategies to study cartilage development, degeneration and regeneration

Maumita Bhattacharjee; Jeannine Coburn; Matteo Centola; Sumit Murab; Andrea Barbero; David L Kaplan; Ivan Martin; Sourabh Ghosh

doi:10.1016/j.addr.2014.08.010

Tissue engineering strategies to study cartilage development, degeneration and regeneration

Adv Drug Deliv Rev. 2015 Apr:84:107-22. doi: 10.1016/j.addr.2014.08.010. Epub 2014 Aug 29.

Authors

Maumita Bhattacharjee¹, Jeannine Coburn², Matteo Centola³, Sumit Murab¹, Andrea Barbero³, David L Kaplan⁴, Ivan Martin⁵, Sourabh Ghosh⁶

Affiliations

¹ Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
² Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
³ Department of Surgery, University Hospital Basel, University of Basel, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
⁴ Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.
⁵ Department of Surgery, University Hospital Basel, University of Basel, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland. Electronic address: ivan.martin@usb.ch.
⁶ Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India. Electronic address: sghosh08@textile.iitd.ac.in.

PMID: 25174307
DOI: 10.1016/j.addr.2014.08.010

Abstract

Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm.

Keywords: Cartilage tissue; Developmental biology; Drug targets; In vitro models; Scaffolds; Signals.

Publication types

Review

MeSH terms

Cartilage / pathology
Cartilage / physiology*
Chondrogenesis / physiology*
Humans
In Vitro Techniques / methods
Regeneration / physiology*
Stem Cell Transplantation / methods
Tissue Engineering / methods*