Synthesis and in vitro evaluation of thiododecaborated α, α- cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy

Amino Acids. 2014 Dec;46(12):2715-20. doi: 10.1007/s00726-014-1829-5. Epub 2014 Aug 31.

Abstract

Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, α, α-cycloalkyl amino acids containing thiododecaborate ([B12H11](2-)-S-) units were designed and synthesized as novel boron delivery agents for BNCT. In the present study, new thiododecaborate α, α-cycloalkyl amino acids were synthesized, and biological evaluation of the boron compounds as boron carrier for BNCT was carried out.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Boron Compounds / chemical synthesis*
  • Boron Compounds / pharmacology*
  • Boron Neutron Capture Therapy / instrumentation*
  • Brain Neoplasms / physiopathology
  • Brain Neoplasms / radiotherapy*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / pharmacology*

Substances

  • Amino Acids
  • Boron Compounds
  • Radiopharmaceuticals