Age-dependent hepatocyte transplantation for functional liver tissue reconstitution

Methods Mol Biol. 2014:1213:41-50. doi: 10.1007/978-1-4939-1453-1_4.

Abstract

The transplantation of hepatocytes could be an alternative therapeutic option to the whole organ transplantation for the treatment of end-stage liver diseases. However, this cell-based therapy needs the understanding of the molecular mechanisms to improve efficacy. This chapter includes a detailed method of a rat model for liver regeneration studies after age-dependent hepatocyte transplantation.

MeSH terms

  • Age Factors
  • Animals
  • Cell- and Tissue-Based Therapy*
  • Hepatocytes / transplantation*
  • Immunohistochemistry
  • Liver / cytology
  • Liver / metabolism
  • Liver / surgery
  • Liver Regeneration*
  • Rats
  • Transplantation Conditioning