Building a temperature-sensitive ion channel

Ming-Feng Tsai; Christopher Miller

doi:10.1016/j.cell.2014.08.008

Building a temperature-sensitive ion channel

Cell. 2014 Aug 28;158(5):977-979. doi: 10.1016/j.cell.2014.08.008.

Authors

Ming-Feng Tsai¹, Christopher Miller²

Affiliations

¹ Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA.
² Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA. Electronic address: cmiller@brandeis.edu.

PMID: 25171401
DOI: 10.1016/j.cell.2014.08.008

Abstract

The biophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack. Chowdhury, et al. use a protein engineering approach to render a temperature-insensitive voltage-gated channel cold- or heat-responsive to reveal principles for temperature-gating and a plausible model for molecularly enabling this mode of environmental responsiveness.

Publication types

Comment

MeSH terms

Animals
Humans
Ion Channels / chemistry*
Ion Channels / metabolism*
Protein Engineering*

Substances

Ion Channels