Neutralizing the HIV reservoir

Matthew D Marsden; Jerome A Zack

doi:10.1016/j.cell.2014.08.010

Neutralizing the HIV reservoir

Cell. 2014 Aug 28;158(5):971-972. doi: 10.1016/j.cell.2014.08.010.

Authors

Matthew D Marsden¹, Jerome A Zack²

Affiliations

¹ Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.

Abstract

Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.

Publication types

Comment

MeSH terms

Animals
Antibodies, Neutralizing / administration & dosage*
HIV Infections / immunology*
HIV-1 / drug effects*
Humans
Transcription, Genetic / drug effects*
Virus Latency / drug effects*

Substances

Antibodies, Neutralizing

Abstract

Publication types

MeSH terms

Substances

Grants and funding