Genomic characterization of a rotavirus G8P[1] detected in a child with diarrhea reveal direct animal-to-human transmission

Infect Genet Evol. 2014 Oct:27:402-7. doi: 10.1016/j.meegid.2014.08.015. Epub 2014 Aug 25.

Abstract

Group A rotavirus is a major cause of severe gastroenteritis in children and young animals. During a retrospective analysis of samples collected from Paraguayan children under 5 years old with diarrhea, and previously negative for rotavirus and norovirus, we detected the presence of bovine rotavirus sequences by viral metagenomics. Nucleic acid was extracted direct from stool sample and determined to be G8P[1]. The genomic analyzes revealed that the strain presents an Artiodactyl-like genome (G8-P[1]-I2-R2-C2-M1-Ax-N2-T6-E12-H3) suggesting a direct animal-to-human transmission.

Keywords: Bovine-like rotavirus G8P[1]; Interspecies transmission; Rotavirus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Child, Preschool
  • Diarrhea / virology*
  • Gastroenteritis / virology
  • Genes, Viral
  • Genome, Viral*
  • Genomics*
  • Humans
  • Infant
  • Infant, Newborn
  • Molecular Sequence Data
  • Phylogeny
  • Retrospective Studies
  • Rotavirus / classification
  • Rotavirus / genetics*
  • Rotavirus Infections / transmission*
  • Rotavirus Infections / virology*

Associated data

  • GENBANK/KJ803831
  • GENBANK/KJ803832
  • GENBANK/KJ803833
  • GENBANK/KJ803834
  • GENBANK/KJ803835
  • GENBANK/KJ803836
  • GENBANK/KJ803837
  • GENBANK/KJ803838
  • GENBANK/KJ803839
  • GENBANK/KJ803840