Near-infrared emitting fluorescent BODIPY nanovesicles for in vivo molecular imaging and drug delivery

Li Quan; Shi Liu; Tingting Sun; Xingang Guan; Wenhai Lin; Zhigang Xie; Yubin Huang; Yiqing Wang; Xiabin Jing

doi:10.1021/am5042115

Near-infrared emitting fluorescent BODIPY nanovesicles for in vivo molecular imaging and drug delivery

ACS Appl Mater Interfaces. 2014 Sep 24;6(18):16166-73. doi: 10.1021/am5042115. Epub 2014 Sep 4.

Authors

Li Quan¹, Shi Liu, Tingting Sun, Xingang Guan, Wenhai Lin, Zhigang Xie, Yubin Huang, Yiqing Wang, Xiabin Jing

Affiliation

¹ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.

PMID: 25159231
DOI: 10.1021/am5042115

Abstract

Near-infrared fluorescent nanovesicles were prepared by self-assembly of block copolymer hydrophilic poly(ethylene glycol) boron-dipyrromethenes in aqueous solution. The fluorescence enhancement induced by dissociation of nanovesicles could be used as a smart imaging and diagnostic tool. This nanovesicle could encapsulate the antitumor drug, and provide a powerful platform for imaging-guided tumor-specific drug delivery and therapy.

Keywords: BODIPY; drug delivery; in vivo imaging; nanovesicles; near-infrared.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacokinetics
Boron Compounds / chemistry*
Docetaxel
Drug Carriers / chemistry*
Fluorescent Dyes / chemistry*
Hep G2 Cells
Humans
Mice
Molecular Imaging / methods*
Particle Size
Spectroscopy, Near-Infrared
Taxoids / chemistry
Taxoids / pharmacokinetics
Xenograft Model Antitumor Assays

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Antineoplastic Agents
Boron Compounds
Drug Carriers
Fluorescent Dyes
Taxoids
Docetaxel