A novel graphene oxide based fluorescent nanosensing strategy with hybridization chain reaction signal amplification for highly sensitive biothiol detection

Chem Commun (Camb). 2014 Oct 14;50(80):11879-82. doi: 10.1039/c4cc05309e.

Abstract

A novel fluorescent nanosensor has been developed for detecting biothiols including cysteine and glutathione using graphene oxide based hairpin DNA-selective fluorescence quenching and thymine-Hg(II)-thymine coordination-controlled hybridization chain reaction, which provides a simple but the most sensitive platform for biothiol assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods
  • Cysteine / analysis*
  • DNA / chemistry
  • Fluorescent Dyes / chemistry*
  • Glutathione / analysis*
  • Graphite / chemistry*
  • Nanostructures / chemistry*
  • Oxides / chemistry*
  • Thymine / chemistry

Substances

  • Fluorescent Dyes
  • Oxides
  • Graphite
  • DNA
  • Glutathione
  • Cysteine
  • Thymine