Th17 cells in inflammation and autoimmunity

Ram Pyare Singh; Sascha Hasan; Sherven Sharma; Saranpreet Nagra; Dean T Yamaguchi; David T W Wong; Bevra H Hahn; Awlad Hossain

doi:10.1016/j.autrev.2014.08.019

Th17 cells in inflammation and autoimmunity

Autoimmun Rev. 2014 Dec;13(12):1174-81. doi: 10.1016/j.autrev.2014.08.019. Epub 2014 Aug 23.

Authors

Ram Pyare Singh¹, Sascha Hasan², Sherven Sharma³, Saranpreet Nagra⁴, Dean T Yamaguchi³, David T W Wong⁵, Bevra H Hahn⁴, Awlad Hossain⁴

Affiliations

¹ Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA; Research Service, Veterans Affairs Greater Los Angeles Health Care System, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA. Electronic address: rsingh@ucla.edu.
² Sanguine Biosciences Inc, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
³ Research Service, Veterans Affairs Greater Los Angeles Health Care System, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
⁴ Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
⁵ UCLA School of Dentistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.

PMID: 25151974
DOI: 10.1016/j.autrev.2014.08.019

Abstract

T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.

Keywords: Autoimmunity; Cancer; Mesenchymal stem cells; Sex hormones; Systemic lupus erythematosus; Th17.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Autoimmune Diseases / immunology
Autoimmunity*
Gonadal Steroid Hormones / immunology
Humans
Inflammation / immunology
Interleukin-17 / immunology
Mesenchymal Stem Cells / immunology
Th17 Cells / immunology*

Substances

Gonadal Steroid Hormones
Interleukin-17

Abstract

Publication types

MeSH terms

Substances

Grants and funding